RefLab has extensive experience in studies employing the microdialysis technique. Microdialysis has many applications:
- In vivo and in vitro studies
- Animal and human studies
- Measuring a wide range of biomarkers
- Translational studies bridging in vivo animal studies to in vivo human studies
Please contact Professor Per Stahl Skov pss@reflab.dk to receive further information on development projects.
Human Skin
| Administration Challenge | Pathogen/challenge* | Drug** | Drug + Challenge*** |
|---|---|---|---|
| Intra cutaneous Injection | X | X | (X) |
| Intra-probe drug delivery | X | X | X |
| Topical Application | (X) | X | X |
* Specific or unspecific activation of cells localized in the skin
** Effect of drug on cells localized in skin. Adverse or toxicologic
*** Effect of drug on activation of cells localized in the skin
Tissues
- Human and animal skin (minipig, mouse, rat) – microdialysis
- Human and mouse peripheral lung & bronchial tissue (chopped lung and microdialysis)
Cells
- Mast Cells
- Basophils
- T-cells
- Fibroblasts
- Keratinocytes
- Dendritic Cells
Mediators
Preformed: (MW < 1 kDa): Histamine
(MW about 60 kDa): Tryptase
Newly synthesized: Leukotrienes, Prostagladines, Bradykinin & Neuropeptides
Induced: Cytokines, Chemokines & Growth Factors