microdialysisRefLab has extensive experience in studies employing the microdialysis technique. Microdialysis has many applications:

  • In vivo and in vitro studies
  • Animal and human studies
  • Measuring a wide range of biomarkers
  • Translational studies bridging in vivo animal studies to in vivo human studies

Please contact Professor Per Stahl Skov pss@reflab.dk or Senior Scientist Sidsel Falkencrone sfal@reflab.dk to receive further information on development projects.

Human Skin
Administration ChallengePathogen/challenge*Drug**Drug + Challenge***
Intra cutaneous Injection

X

X

(X)

Intra-probe drug delivery

X

X

X

Topical Application

(X)

X

X

* Specific or unspecific activation of cells localized in the skin
** Effect of drug on cells localized in skin. Adverse or toxicologic
*** Effect of drug on activation of cells localized in the skin

Tissues
  • Human and animal skin (minipig, mouse, rat) – microdialysis
  • Human and mouse peripheral lung & bronchial tissue (chopped lung and microdialysis)
Cells
  • Mast Cells
  • Basophils
  • T-cells
  • Fibroblasts
  • Keratinocytes
  • Dendritic Cells
Mediators

Preformed: (MW < 1 kDa): Histamine
(MW about 60 kDa): Tryptase

Newly synthesized: Leukotrienes, Prostagladines, Bradykinin & Neuropeptides

Induced: Cytokines, Chemokines & Growth Factors