platzhalterRefLab is currently involved in R&D projects concerning the following areas:

  • Food allergy
  • Drug allergy
  • Genetically modified food
  • Recombinant allergens.
  • Signal transduction in basophils
  • Basophil chemotaxis
  • Chemokine receptors on basophils
  • Autoantibodies for IgE and its receptor
  • chronic urticarial

In vitro skin microdialysis (SKIM) to detect biomarkers released from different cell types in human or animal skin:

The technique is used in different types of studies:

  • Allergic or allergy like adverse effects of drugs (observed or potential)
  • Anti-allergic effects of new drugs (administration: intradermal injection (ID), intra probe drug delivery (IPD) or topical).
  • Mechanisms in allergic-inflammatory reactions (Type I allergy, Chronic urticaria & autoimmune reactions)

In vitro release of biomarkers from human blood/other cells (HBR) or animal blood/other cells (ABR):

  • Allergic or allergy like adverse effects of drugs (observed or potential)
  • Anti-allergic effects of new drugs
  • Detection of biological activity of allergens
  • Identification of allergens in food
  • Monitoring effect of immunotherapy or other treatment
  • Diagnostic, clinical study